The Sanctuary is a safe haven in Calakmul, Mexico for the Loric. It was built by the Mayans centuries ago and is still there. It is protected by ancient power, which Mogadorians adversaries will not be able to set foot on its grounds, without being severely burned. Only the Garde are allowed to enter it. Setrákus Ra collects the fallen Garde's pendants with hopes that they will be able to be used to get in the Sanctuary. Six, Marina, and Adam journey there and speak to the Lorien Entity, which results to what Marina says to be Lorien spreading through Earth.

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